Pub. Date : 2005 Jan 7
PMID : 15531579
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Some studies indicate that mimosine prevents the initiation of DNA replication, whereas other studies indicate that mimosine disrupts elongation of the replication fork by impairing deoxyribonucleotide synthesis by inhibiting the activity of the iron-dependent enzyme ribonucleotide reductase and the transcription of the cytoplasmic serine hydroxymethyltransferase gene (SHMT1). | Mimosine | serine hydroxymethyltransferase 1 | Homo sapiens |
| 2 | Some studies indicate that mimosine prevents the initiation of DNA replication, whereas other studies indicate that mimosine disrupts elongation of the replication fork by impairing deoxyribonucleotide synthesis by inhibiting the activity of the iron-dependent enzyme ribonucleotide reductase and the transcription of the cytoplasmic serine hydroxymethyltransferase gene (SHMT1). | Mimosine | serine hydroxymethyltransferase 1 | Homo sapiens |
| 3 | In this study, the mechanism for mimosine-induced inhibition of SHMT1 transcription was elucidated. | Mimosine | serine hydroxymethyltransferase 1 | Homo sapiens |
| 4 | A mimosine-responsive transcriptional element was localized within the first 50 base pairs of the human SHMT1 promoter by deletion analyses and gel mobility shift assays. | Mimosine | serine hydroxymethyltransferase 1 | Homo sapiens |
| 5 | MCF-7 cells cultured in zinc-depleted medium for more than 16 days were viable and lacked cytoplasmic serine hydroxymethyltransferase protein, confirming that mimosine inhibits SHMT1 transcription by chelating zinc. | Mimosine | serine hydroxymethyltransferase 1 | Homo sapiens |