Title : Structural basis of constitutive activity and a unique nucleotide binding mode of human Pim-1 kinase.

Pub. Date : 2005 Feb 18

PMID : 15525646






1 Functional Relationships(s)
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1 2) The hinge region has a novel architecture and hydrogen-bonding pattern, which not only expand the ATP pocket but also serve to establish unambiguously the alignment of the Pim-1 hinge region with that of other kinases. Adenosine Triphosphate Pim-1 proto-oncogene, serine/threonine kinase Homo sapiens