Title : Evidence for a new human CYP1A1 regulation pathway involving PPAR-alpha and 2 PPRE sites.

Pub. Date : 2004 Nov

PMID : 15521013






1 Functional Relationships(s)
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1 RESULTS: We show that peroxisome proliferator-activated receptor-alpha agonists (WY-14643, bezafibrate, clofibrate, and phthalate) induce human cytochrome P450 1A1 gene expression, whereas 2,4-thiazolidinedione, a specific peroxisome proliferator-activated receptor-gamma agonist, represses it. phthalic acid peroxisome proliferator activated receptor gamma Homo sapiens