Title : Superoxide generation from Kupffer cells contributes to hepatocarcinogenesis: studies on NADPH oxidase knockout mice.

Pub. Date : 2005 Feb

PMID : 15513930

1 Functional Relationships(s)
Compound Name
Protein Name
1 These studies suggest two conclusions: (i) superoxide generation by phagocytes during liver damage and inflammation aggravates genotoxic and cytotoxic effects in hepatocytes and may thus contribute to tumor initiation and promotion; (ii) DEN has a direct stimulatory effect on KC to release superoxide and TNFalpha. Superoxides tumor necrosis factor Mus musculus