Pub. Date : 2004 Aug
PMID : 15492480
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Role of aberrant iron homeostasis in the upregulation of transforming growth factor-beta1 in the kidney of angiotensin II-induced hypertensive rats. | Iron | angiotensinogen | Rattus norvegicus |
2 | We have previously shown that abnormal iron metabolism might be one underlying mechanism of the renal damage observed in the angiotensin II-infused rat. | Iron | angiotensinogen | Rattus norvegicus |
3 | The purpose of the present study was to examine the effects of an iron chelator and a free radical scavenger on the angiotensin II-induced upregulation of TGF-beta1 in the kidney. | Iron | angiotensinogen | Rattus norvegicus |
4 | Although tubular cells that overexpressed TGF-beta1 did not contain iron particles, angiotensin II-induced TGF-beta1 upregulation was suppressed by the iron chelator and the free radical scavenger. | Iron | angiotensinogen | Rattus norvegicus |
5 | Collectively, these data suggest that the renal iron overload and presumed subsequent increase in oxidative stress play a role in angiotensin II-induced upregulation of the mRNAs of TGF-beta1 and collagen types I and IV in the kidney. | Iron | angiotensinogen | Rattus norvegicus |