Pub. Date : 2004 Oct 15
PMID : 15492284
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | We found that CDDO-Me not only activated caspase-8 but also induced expression of DRs, particularly DR5, in a p53-independent mechanism. | bardoxolone methyl | TNF receptor superfamily member 10b | Homo sapiens |
2 | Moreover, silencing of DR5 expression using small interfering RNA suppressed apoptosis induced by CDDO-Me alone or by combination of CDDO-Me and TRAIL, indicating that DR5 up-regulation is required for induction of apoptosis by CDDO-Me and for enhancement of TRAIL-induced apoptosis by CDDO-Me. | bardoxolone methyl | TNF receptor superfamily member 10b | Homo sapiens |
3 | Moreover, silencing of DR5 expression using small interfering RNA suppressed apoptosis induced by CDDO-Me alone or by combination of CDDO-Me and TRAIL, indicating that DR5 up-regulation is required for induction of apoptosis by CDDO-Me and for enhancement of TRAIL-induced apoptosis by CDDO-Me. | bardoxolone methyl | TNF receptor superfamily member 10b | Homo sapiens |
4 | Moreover, silencing of DR5 expression using small interfering RNA suppressed apoptosis induced by CDDO-Me alone or by combination of CDDO-Me and TRAIL, indicating that DR5 up-regulation is required for induction of apoptosis by CDDO-Me and for enhancement of TRAIL-induced apoptosis by CDDO-Me. | bardoxolone methyl | TNF receptor superfamily member 10b | Homo sapiens |
5 | Moreover, silencing of DR5 expression using small interfering RNA suppressed apoptosis induced by CDDO-Me alone or by combination of CDDO-Me and TRAIL, indicating that DR5 up-regulation is required for induction of apoptosis by CDDO-Me and for enhancement of TRAIL-induced apoptosis by CDDO-Me. | bardoxolone methyl | TNF receptor superfamily member 10b | Homo sapiens |