Pub. Date : 2004 Aug
PMID : 15491054
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Based on preliminary studies, our working hypothesis was that incorporation of AmpB into mixed micelles composed of Peceol would significantly enhance gastro-intestinal (GI) tract absorption by increasing lymphatic drug transport and decreasing P-glycoprotein (PGP)-mediated drug efflux. | Amphotericin B | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | Based on preliminary studies, our working hypothesis was that incorporation of AmpB into mixed micelles composed of Peceol would significantly enhance gastro-intestinal (GI) tract absorption by increasing lymphatic drug transport and decreasing P-glycoprotein (PGP)-mediated drug efflux. | Amphotericin B | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | CONCLUSIONS: Taken together, these findings suggest that Peceol increases the gastrointestinal absorption of AmpB by increasing the amount of drug that is transported through the mesenteric lymph duct and by decreasing mdr-1 mRNA and PGP protein expression, resulting in lower PGP-mediated AmpB efflux. | Amphotericin B | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 4 | CONCLUSIONS: Taken together, these findings suggest that Peceol increases the gastrointestinal absorption of AmpB by increasing the amount of drug that is transported through the mesenteric lymph duct and by decreasing mdr-1 mRNA and PGP protein expression, resulting in lower PGP-mediated AmpB efflux. | Amphotericin B | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 5 | CONCLUSIONS: Taken together, these findings suggest that Peceol increases the gastrointestinal absorption of AmpB by increasing the amount of drug that is transported through the mesenteric lymph duct and by decreasing mdr-1 mRNA and PGP protein expression, resulting in lower PGP-mediated AmpB efflux. | Amphotericin B | ATP binding cassette subfamily B member 1 | Homo sapiens |