Title : Cobalamin (vitamin B12) binding, phylogeny, and synteny of human transcobalamin.

Pub. Date : 2004 Nov 15

PMID : 15488467






1 Functional Relationships(s)
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1 These studies show that (a) two of the three polar residues, S174, T177, or D176 and two of the three conserved alanine residues, A179 and A184 present in the 15-residue evolutionary conserved region are essential for Cbl-binding by human TC, and (b) TC gene is transferred in a syntenic manner to different chromosomes, at least before the divergence of mouse/rat and human. Alanine Cbl proto-oncogene Homo sapiens