Pub. Date : 2004 Oct
PMID : 15480986
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Genetic variants of the mannan-binding lectin are associated with immune reactivity to mannans in Crohn"s disease. | Mannans | mannose binding lectin 2 | Homo sapiens |
| 2 | T-cell proliferation in response to mannan stimulation was observed in ASCA-positive patients and could be inhibited by the addition of MBL. | Mannans | mannose binding lectin 2 | Homo sapiens |
| 3 | Homozygous or compound heterozygous MBL mutations in the exon 1 and promoter occurred in 12 patients with cellular or humoral immune reactivity to mannan as compared with only 1 nonreactive patient (P < 0.0001). | Mannans | mannose binding lectin 2 | Homo sapiens |
| 4 | Thus, we propose that enhanced mannan exposure stimulates specific immune responses in a subgroup of CD patients with genetically determined low MBL concentrations. | Mannans | mannose binding lectin 2 | Homo sapiens |