Protein Name mannose binding lectin 2
Organism Homo sapiens
Gene ID 4153
Gene Symbol

MBL2

UniProt P11226 (MBL2_HUMAN)
Relationships Total Number of functionally related compound(s) : 212
Total Number of Articles : 466
Description

mannose binding lectin 2

Gene Summary

This gene encodes the soluble mannose-binding lectin or mannose-binding protein found in serum. The protein encoded belongs to the collectin family and is an important element in the innate immune system. The protein recognizes and binds to mannose and N-acetylglucosamine on many microorganisms, including bacteria, yeast, and viruses including influenza virus, HIV and SARS-CoV. This binding activates the classical complement pathway. Deficiencies of this gene have been associated with susceptibility to autoimmune and infectious diseases. [provided by RefSeq, Jun 2020]

synonyms
  • mannose-binding protein C
  • collectin-1
  • mannan-binding lectin
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Properties