Title : Reduced PTEN expression predicts relapse in patients with breast carcinoma treated by tamoxifen.

Pub. Date : 2005 Feb

PMID : 15475931






4 Functional Relationships(s)
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1 Reduced PTEN expression predicts relapse in patients with breast carcinoma treated by tamoxifen. Tamoxifen phosphatase and tensin homolog Homo sapiens
2 Decreased PTEN and/or increased protein kinase B/Akt activity in breast cancer cells has recently been associated with resistance to tamoxifen-induced apoptosis. Tamoxifen phosphatase and tensin homolog Homo sapiens
3 In this study, we have evaluated PTEN expression by immunohistochemistry in 100 tamoxifen-treated ER-alpha-positive breast cancer patients. Tamoxifen phosphatase and tensin homolog Homo sapiens
4 In summary, our results showed a strong association between downregulation of PTEN expression in ER-alpha-positive tumors and failure to tamoxifen treatment. Tamoxifen phosphatase and tensin homolog Homo sapiens