Pub. Date : 2005 Feb
PMID : 15475931
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Reduced PTEN expression predicts relapse in patients with breast carcinoma treated by tamoxifen. | Tamoxifen | phosphatase and tensin homolog | Homo sapiens |
| 2 | Decreased PTEN and/or increased protein kinase B/Akt activity in breast cancer cells has recently been associated with resistance to tamoxifen-induced apoptosis. | Tamoxifen | phosphatase and tensin homolog | Homo sapiens |
| 3 | In this study, we have evaluated PTEN expression by immunohistochemistry in 100 tamoxifen-treated ER-alpha-positive breast cancer patients. | Tamoxifen | phosphatase and tensin homolog | Homo sapiens |
| 4 | In summary, our results showed a strong association between downregulation of PTEN expression in ER-alpha-positive tumors and failure to tamoxifen treatment. | Tamoxifen | phosphatase and tensin homolog | Homo sapiens |