Title : Beta2-subunit-containing nicotinic acetylcholine receptors are critical for dopamine-dependent locomotor activation following repeated nicotine administration.

Pub. Date : 2004

PMID : 15464132






1 Functional Relationships(s)
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1 Knockout mice lacking the beta2 subunit of the nAChR did not show locomotor activation in response to chronic nicotine exposure, suggesting that beta2* nAChRs are critical for ongoing activation of the dopamine system by chronic nicotine administration and the resulting locomotor activation in mice. Nicotine cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus