Title : Cyclooxygenase inhibition in human monocytes increases endotoxin-induced TNF alpha without affecting cyclooxygenase-2 expression.

Pub. Date : 2004 Oct 6

PMID : 15464057






1 Functional Relationships(s)
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1 Indomethacin or lysine-acetylsalicylic acid concentration-dependently inhibited prostaglandin E(2) biosynthesis and, at concentrations causing near-complete inhibition, enhanced TNFalpha mRNA and protein expression without significantly influencing cyclooxygenase-2 mRNA. Indomethacin prostaglandin-endoperoxide synthase 2 Homo sapiens