Title : 17beta-estradiol up-regulates prostacyclin production in cultured human uterine myometrial cells via augmentation of both cyclooxygenase-1 and prostacyclin synthase expression.

Pub. Date : 2004 Oct

PMID : 15458742






3 Functional Relationships(s)
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1 17beta-estradiol up-regulates prostacyclin production in cultured human uterine myometrial cells via augmentation of both cyclooxygenase-1 and prostacyclin synthase expression. Estradiol prostaglandin-endoperoxide synthase 1 Homo sapiens
2 Stimulation with 40-nM 17beta-estradiol significantly up-regulated protein and mRNA expression of both COX-1 and PGIS. Estradiol prostaglandin-endoperoxide synthase 1 Homo sapiens
3 CONCLUSION: 17beta-Estradiol from placenta may contribute to the augmentation of PGI(2) production in the human myometrium in the middle of gestation via up-regulation of both COX-1 and PGIS expression. Estradiol prostaglandin-endoperoxide synthase 1 Homo sapiens