Title : CYP 17 and CYP 19 inhibitors. Evaluation of fluorine effects on the inhibiting activity of regioselectively fluorinated 1-(Naphthalen-2-ylmethyl)imidazoles.

Pub. Date : 2004 Apr

PMID : 15449729






1 Functional Relationships(s)
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1 Compared with the nonfluorinated parent compounds 1i-1, fluorinated 1-(naphth-2-yl)methylimidazoles 1a-h turned out to be potent inhibitors of CYP17 and CYP19 enzymes. 1-(naphth-2-yl)methylimidazoles cytochrome P450 family 19 subfamily A member 1 Homo sapiens