Title : Conversion of the HIV protease inhibitor nelfinavir to a bioactive metabolite by human liver CYP2C19.

Pub. Date : 2004 Dec

PMID : 15448116






1 Functional Relationships(s)
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1 The inducibility of CYP2C19 by agents (e.g., rifampicin) often taken concurrently with nelfinavir, together with this P450"s known polymorphic nature, may thus be important determinants of nelfinavir"s antiviral potency. Rifampin cytochrome P450 family 2 subfamily C member 19 Homo sapiens