Title : Aberrant p53 alters DNA damage checkpoints in response to cisplatin: downregulation of CDK expression and activity.

Pub. Date : 2004 Dec 10

PMID : 15386387






1 Functional Relationships(s)
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1 In contrast, cells stably expressing H179L-p53 arrested in S-phase following cisplatin treatment, which correlated with a marked decrease in the expression of cdc2, cyclin B1 and cyclin A, and a decrease in CDK2 and cyclin A-associated kinase activity. Cisplatin cyclin dependent kinase 1 Homo sapiens