Pub. Date : 2004 Sep 15
PMID : 15374966
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Retinoic acid increases the expression of p53 and proapoptotic caspases and sensitizes keratinocytes to apoptosis: a possible explanation for tumor preventive action of retinoids. | Tretinoin | tumor protein p53 | Homo sapiens |
2 | Analysis by real-time PCR and Western blot revealed that ATRA treatment strongly increased the mRNA and protein expression of p53 and caspase-3, -6, -7, and -9, which are key regulators of apoptosis. | Tretinoin | tumor protein p53 | Homo sapiens |
3 | UVB irradiation of ATRA-treated cells but not of control cells led to the accumulation of p53 protein and of its target gene Noxa. | Tretinoin | tumor protein p53 | Homo sapiens |
4 | Inhibition of p53 and caspases with alpha-pifithrin and z-Val-Ala-Asp-fluoromethyl ketone, respectively, blocked UVB- and doxorubicin-induced apoptosis in ATRA-treated KCs. | Tretinoin | tumor protein p53 | Homo sapiens |
5 | Analogous to the observed ATRA effects in monolayer cultures, in vitro-generated organotypic skin cultures reacted with up-regulation of p53 and proapoptotic caspases and displayed increased sensitivity to UVB-induced apoptosis. | Tretinoin | tumor protein p53 | Homo sapiens |