PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15374966-0	2004	Retinoic acid increases the expression of p53 and proapoptotic caspases and sensitizes keratinocytes to apoptosis: a possible explanation for tumor preventive action of retinoids.	Tretinoin	0-13	tumor protein p53	Homo sapiens	42-45	
15374966-6	2004	Analysis by real-time PCR and Western blot revealed that ATRA treatment strongly increased the mRNA and protein expression of p53 and caspase-3, -6, -7, and -9, which are key regulators of apoptosis.	Tretinoin	57-61	tumor protein p53	Homo sapiens	126-129	
15374966-7	2004	UVB irradiation of ATRA-treated cells but not of control cells led to the accumulation of p53 protein and of its target gene Noxa.	Tretinoin	19-23	tumor protein p53	Homo sapiens	90-93	
15374966-8	2004	Inhibition of p53 and caspases with alpha-pifithrin and z-Val-Ala-Asp-fluoromethyl ketone, respectively, blocked UVB- and doxorubicin-induced apoptosis in ATRA-treated KCs.	Tretinoin	155-159	tumor protein p53	Homo sapiens	14-17	
15374966-9	2004	Analogous to the observed ATRA effects in monolayer cultures, in vitro-generated organotypic skin cultures reacted with up-regulation of p53 and proapoptotic caspases and displayed increased sensitivity to UVB-induced apoptosis.	Tretinoin	26-30	tumor protein p53	Homo sapiens	137-140