Title : Role of hepatic and intestinal cytochrome P450 3A and 2B6 in the metabolism, disposition, and miotic effects of methadone.

Pub. Date : 2004 Sep

PMID : 15371986






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Methadone undergoes N -demethylation to the primary metabolite 2-ethyl-1,5-dimethyl-3,3-diphenylpyrrolinium (EDDP), catalyzed in vitro by intestinal, hepatic, and expressed cytochrome P450 (CYP) 3A4. 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine cytochrome P450 family 3 subfamily A member 4 Homo sapiens