Title : ZD6474, a vascular endothelial growth factor receptor tyrosine kinase inhibitor with additional activity against epidermal growth factor receptor tyrosine kinase, inhibits orthotopic growth and angiogenesis of gastric cancer.

Pub. Date : 2004 Sep

PMID : 15367698






3 Functional Relationships(s)
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1 The purpose of this study was to examine the effects of ZD6474, an inhibitor of inhibitor of VEGF receptor (VEGFR) tyrosine kinase with additional activity against EGF receptor (EGFR), on tumor growth and angiogenesis in an orthotopic model of gastric cancer. vandetanib epidermal growth factor receptor Homo sapiens
2 The purpose of this study was to examine the effects of ZD6474, an inhibitor of inhibitor of VEGF receptor (VEGFR) tyrosine kinase with additional activity against EGF receptor (EGFR), on tumor growth and angiogenesis in an orthotopic model of gastric cancer. vandetanib epidermal growth factor receptor Homo sapiens
3 EGF-mediated activation of EGFR and Erk-1/2 was decreased in tumor cells after ZD6474 treatment. vandetanib epidermal growth factor receptor Homo sapiens