Title : Simultaneous substitution of phenylalanine-305 and aspartate-318 of rat pregnane X receptor with the corresponding human residues abolishes the ability to transactivate the CYP3A23 promoter.

Pub. Date : 2005 Feb

PMID : 15367577






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Pregnenolone 16alpha-carbonitrile (PCN), a glucocorticoid antagonist, efficaciously activates rodent but not human PXR. Pregnenolone Carbonitrile nuclear receptor subfamily 1 group I member 2 Homo sapiens
2 Pregnenolone 16alpha-carbonitrile (PCN), a glucocorticoid antagonist, efficaciously activates rodent but not human PXR. Pregnenolone Carbonitrile nuclear receptor subfamily 1 group I member 2 Homo sapiens