Pub. Date : 2004 Sep
PMID : 15362034
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We used a loss-of-function approach to investigate whether CLA ameliorated colitis through a peroxisome proliferator-activated receptor gamma (PPAR gamma)-dependent mechanism. | Linoleic Acids, Conjugated | peroxisome proliferator activated receptor gamma | Mus musculus |
| 2 | We used a loss-of-function approach to investigate whether CLA ameliorated colitis through a peroxisome proliferator-activated receptor gamma (PPAR gamma)-dependent mechanism. | Linoleic Acids, Conjugated | peroxisome proliferator activated receptor gamma | Mus musculus |
| 3 | METHODS: The expression of PPAR gamma, delta, and their target genes in the colon of mice fed control or CLA-supplemented diets was assayed after a 7-day dextran sodium sulfate (DSS) challenge by quantitative real-time polymerase chain reaction (PCR). | Linoleic Acids, Conjugated | peroxisome proliferator activated receptor gamma | Mus musculus |
| 4 | Loss of the PPAR gamma gene in the colon abrogated the beneficial effects of CLA in DSS colitis. | Linoleic Acids, Conjugated | peroxisome proliferator activated receptor gamma | Mus musculus |
| 5 | CONCLUSIONS: Our studies provide molecular evidence in vivo, suggesting that CLA ameliorates colitis through a PPAR gamma-dependent mechanism. | Linoleic Acids, Conjugated | peroxisome proliferator activated receptor gamma | Mus musculus |