Title : Stimulation of cyclic GMP efflux in human melanocytes by hypergravity generated by centrifugal acceleration.

Pub. Date : 2004 Oct

PMID : 15357833






1 Functional Relationships(s)
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1 Here we report that long-term application of hypergravity (up to 5 g for 24 h) stimulated cGMP efflux in cultured melanocytes and in non-metastatic melanoma cells in the presence of 0.1 mM 3-isobutyl-1-methylxanthine (IBMX), a non-selective phosphodiesterase (PDE) inhibitor. 1-Methyl-3-isobutylxanthine phosphodiesterase 5A Homo sapiens