Title : Construction of a cyclin D1-Cdk2 fusion protein to model the biological functions of cyclin D1-Cdk2 complexes.

Pub. Date : 2004 Nov 12

PMID : 15355984






4 Functional Relationships(s)
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1 This report demonstrates that Cdk2 in cyclin D1-Cdk2 complexes from mammary epithelial cells is phosphorylated on the activating phosphorylation site, Thr(160). Threonine cyclin dependent kinase 2 Homo sapiens
2 This report demonstrates that Cdk2 in cyclin D1-Cdk2 complexes from mammary epithelial cells is phosphorylated on the activating phosphorylation site, Thr(160). Threonine cyclin dependent kinase 2 Homo sapiens
3 The cyclin D1-Cdk2 fusion protein expressed in epithelial cells was phosphorylated on Thr(160) and catalyzed the phosphorylation of Rb on multiple sites in vitro and in vivo. Threonine cyclin dependent kinase 2 Homo sapiens
4 Mutational inactivation of the cyclin D1 domain prevented activating phosphorylation of the Cdk2 domain on Thr(160). Threonine cyclin dependent kinase 2 Homo sapiens