Title : Utility of recombinant enzyme kinetics in prediction of human clearance: impact of variability, CYP3A5, and CYP2C19 on CYP3A4 probe substrates.

Pub. Date : 2004 Dec

PMID : 15342470






1 Functional Relationships(s)
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1 The differences observed in the benzodiazepine metabolite pathway ratios between CYP3A4 and CYP3A5, particularly for 1"- to 4-hydroxymidazolam and alprazolam, provided a useful measure of interindividual differences within the CYP3A family. Alprazolam cytochrome P450 family 3 subfamily A member 4 Homo sapiens