Title : P21Cip1 is a critical mediator of the cytotoxic action of thymidylate synthase inhibitors in colorectal carcinoma cells.

Pub. Date : 2004 Sep 1

PMID : 15342418






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 P21Cip1, cdk1, cdk2, and cyclin E mRNA expression increased coincident with S-phase accumulation in HT29 cells treated with ZD9331 or 5fluorouracil/leucovorin, as demonstrated by cDNA microarray analyses. Fluorouracil cyclin dependent kinase 2 Homo sapiens