Title : Increased bioavailability of tacrolimus after rectal administration in rats.

Pub. Date : 2004 Sep

PMID : 15340245






1 Functional Relationships(s)
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1 The oral bioavailability of tacrolimus is low and varies considerably in humans due to first-pass metabolism by cytochrome P450 (CYP) 3A4 and the active efflux mediated by P-glycoprotein. Tacrolimus cytochrome P450 family 3 subfamily A member 4 Homo sapiens