Title : Vascular endothelial growth factor transcriptional activation is mediated by hypoxia-inducible factor 1alpha, HDM2, and p70S6K1 in response to phosphatidylinositol 3-kinase/AKT signaling.

Pub. Date : 2004 Oct 29

PMID : 15337760






2 Functional Relationships(s)
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1 The inhibition of PI3K by LY294002 inhibited p70S6K1 and HDM2 activity in the cells. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one MDM2 proto-oncogene Homo sapiens
2 Forced expression of p70S6K1 or HDM2 reversed LY294002-inhibited VEGF transcriptional activation and HIF-1alpha expression. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one MDM2 proto-oncogene Homo sapiens