Title : Rational design of 6-methylsulfonylindoles as selective cyclooxygenase-2 inhibitors.

Pub. Date : 2004 Sep 20

PMID : 15324899






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1 The introduction of 3-arylmethyl, 3-aryloxy and 3-arylthio moieties into a 6-methylsulfonylindole framework using rational drug design led to potent, selective COX-2 inhibitors having efficacy in a rat carrageenan air pouch model. Carrageenan cytochrome c oxidase II, mitochondrial Rattus norvegicus