Title : Induction of granulocyte-macrophage colony-stimulating factor by a new cytokine, ML-1 (IL-17F), via Raf I-MEK-ERK pathway.

Pub. Date : 2004 Aug

PMID : 15316530






2 Functional Relationships(s)
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1 Selective MEK inhibitors, PD98059 and U0126, and Raf1 kinase inhibitor I significantly inhibited ML-1-induced GM-CSF production. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one colony stimulating factor 2 Homo sapiens
2 The combination of PD98059 and Raf1 kinase inhibitor I completely blocked GM-CSF production, whereas 2 protein kinase C inhibitors, Ro-31-7549 and GF109203X, and a phosphatidylinositol 3-kinase inhibitor, LY294002, showed no inhibitory effect. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one colony stimulating factor 2 Homo sapiens