Pub. Date : 2004 Dec 15
PMID : 15315969
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Heparin cofactor II (HCII) is a plasma protein that inhibits thrombin rapidly in the presence of dermatan sulfate or heparin. | Dermatan Sulfate | serine (or cysteine) peptidase inhibitor, clade D, member 1 | Mus musculus |
| 2 | Heparin cofactor II (HCII) is a plasma protein that inhibits thrombin rapidly in the presence of dermatan sulfate or heparin. | Dermatan Sulfate | serine (or cysteine) peptidase inhibitor, clade D, member 1 | Mus musculus |
| 3 | Intravenous administration of porcine skin dermatan sulfate induced a dose-dependent prolongation of the carotid artery occlusion time in HCII(+/+) mice that was not observed in HCII(-/-) animals. | Dermatan Sulfate | serine (or cysteine) peptidase inhibitor, clade D, member 1 | Mus musculus |
| 4 | Intravenous administration of porcine skin dermatan sulfate induced a dose-dependent prolongation of the carotid artery occlusion time in HCII(+/+) mice that was not observed in HCII(-/-) animals. | Dermatan Sulfate | serine (or cysteine) peptidase inhibitor, clade D, member 1 | Mus musculus |
| 5 | Using invertebrate dermatan sulfate preparations, we showed that N-acetylgalactosamine-4-O-sulfate residues are required for the HCII-dependent antithrombotic effect. | Dermatan Sulfate | serine (or cysteine) peptidase inhibitor, clade D, member 1 | Mus musculus |
| 6 | These results indicate that HCII mediates the antithrombotic effect of porcine skin dermatan sulfate after injury to the carotid arterial endothelium in mice, whereas more highly charged dermatan sulfates possess weak antithrombotic activity independent of HCII. | Dermatan Sulfate | serine (or cysteine) peptidase inhibitor, clade D, member 1 | Mus musculus |