Title : Cholesterol, copper, and accumulation of thioflavine S-reactive Alzheimer's-like amyloid beta in rabbit brain.

Pub. Date : 2004

PMID : 15314257






4 Functional Relationships(s)
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1 The cholesterol-induced accumulation of Abeta in rabbit brain is increased when distilled drinking water is supplemented with 0.12 ppm copper ion (as copper sulfate) compared to the cholesterol-induced accumulation of Abeta in rabbit brain of animals given unaltered distilled water. Water amyloid beta (A4) precursor protein Mus musculus
2 The cholesterol-induced accumulation of Abeta in rabbit brain is increased when distilled drinking water is supplemented with 0.12 ppm copper ion (as copper sulfate) compared to the cholesterol-induced accumulation of Abeta in rabbit brain of animals given unaltered distilled water. Water amyloid beta (A4) precursor protein Mus musculus
3 The numbers of affected neurons and the intensity of neuronal Abeta immunoreactivity is consistently increased among animals administered the copper ion in their drinking water. Water amyloid beta (A4) precursor protein Mus musculus
4 The data suggest that there is an accumulation of fibrillar Abeta induced in the brains of rabbits fed a cholesterol diet and administered trace levels of copper ion in their drinking water. Water amyloid beta (A4) precursor protein Mus musculus