Title : Activation of mouse and human peroxisome proliferator-activated receptors (PPARs) by phthalate monoesters.

Pub. Date : 2004 Nov

PMID : 15310864






3 Functional Relationships(s)
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1 A number of phthalate monoesters activated both mouse and human PPARgamma, with similar sensitivity being exhibited by both receptors. phthalic acid peroxisome proliferator activated receptor gamma Homo sapiens
2 These studies show that the potency and efficacy of phthalate monoesters for the activation of PPARalpha and PPARgamma increase with increasing side-chain length. phthalic acid peroxisome proliferator activated receptor gamma Homo sapiens
3 These studies also show that mouse PPARalpha and PPARbeta are generally activated at lower concentrations of phthalate monoesters than human PPARalpha and PPARbeta, and that both mouse and human PPARgamma exhibit similar sensitivity to phthalate monoesters. phthalic acid peroxisome proliferator activated receptor gamma Homo sapiens