Title : Ecto-nucleotidases and nucleoside transporters mediate activation of adenosine receptors on hippocampal mossy fibers by P2X7 receptor agonist 2'-3'-O-(4-benzoylbenzoyl)-ATP.

Pub. Date : 2004 Aug 11

PMID : 15306646






3 Functional Relationships(s)
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1 In agreement with previous findings, the widely used P2X7 agonist 2"-3"-O-(4-benzoylbenzoyl)-adenosine-5"-triphosphate (BzATP) clearly depressed field potentials (fEPSPs); however, no evidence for an involvement of P2X7 receptors could be obtained. BzATP purinergic receptor P2X, ligand-gated ion channel, 7 Mus musculus
2 In agreement with previous findings, the widely used P2X7 agonist 2"-3"-O-(4-benzoylbenzoyl)-adenosine-5"-triphosphate (BzATP) clearly depressed field potentials (fEPSPs); however, no evidence for an involvement of P2X7 receptors could be obtained. BzATP purinergic receptor P2X, ligand-gated ion channel, 7 Mus musculus
3 Taken together, our results indicate that BzATP is extracellularly catabolized to Bz-adenosine and subsequently hetero-exchanged for intracellular adenosine and then depresses mossy fiber fEPSPs through presynaptic A1 receptors rather than through P2X7 receptors. BzATP purinergic receptor P2X, ligand-gated ion channel, 7 Mus musculus