Title : Production of macrophage IL-1beta was inhibited both at the levels of transcription and maturation by caspase-1 following inhalation exposure to isobutyl nitrite.

Pub. Date : 2004 Aug 30

PMID : 15294346






3 Functional Relationships(s)
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1 IL-1beta mRNA transcription was reduced by 35% following nitrite inhalant exposure, consistent with inhibition of activation-induced phosphorylation of macrophage mitogen-activated protein kinase p38. Nitrites interleukin 1 beta Homo sapiens
2 Nitrite inhalant exposure blocked activation-induced increases in caspase-1 activity, consistent with a 50% reduction in 17 kDa IL-1beta shown in Western blots. Nitrites interleukin 1 beta Homo sapiens
3 Thus, exposure to nitrite inhalants reduced macrophage production of IL-1beta by reducing transcription, as well as post-translational processing mediated by caspase-1. Nitrites interleukin 1 beta Homo sapiens