Pub. Date : 2004 Aug
PMID : 15289787
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Effect of the CYP3A5 genotype on the pharmacokinetics of intravenous midazolam during inhibited and induced metabolic states. | Midazolam | cytochrome P450 family 3 subfamily A member 5 | Homo sapiens |
| 2 | OBJECTIVE: Our objective was to investigate the effect of the CYP3A5 genotype on the systemic clearance of midazolam in constitutive, inhibited, and induced metabolic conditions. | Midazolam | cytochrome P450 family 3 subfamily A member 5 | Homo sapiens |
| 3 | The 1"-hydroxymidazolam-to-midazolam area under the plasma concentration-time curve ratio was also significantly lower in the CYP3A5*3/*3 group (0.58 +/- 0.35 versus 1.09 +/- 0.37 for the homozygous wild-type group, P =.026). | Midazolam | cytochrome P450 family 3 subfamily A member 5 | Homo sapiens |
| 4 | However, during cytochrome P450 (CYP) 3A inhibition by itraconazole, individuals carrying the CYP3A5*1 allele were found to be less susceptible to changes in systemic clearance and showed higher 1"-hydroxymidazolam-to-midazolam area under the plasma concentration-time curve ratios, probably resulting from the relatively CYP3A4-specific inhibition caused by itraconazole. | Midazolam | cytochrome P450 family 3 subfamily A member 5 | Homo sapiens |