Title : Backbone dynamics of an oncogenic mutant of Cdc42Hs shows increased flexibility at the nucleotide-binding site.

Pub. Date : 2004 Aug 10

PMID : 15287724






2 Functional Relationships(s)
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1 The F28L mutation of Cdc42Hs is characterized by an increased rate of cycling between the GTP and GDP-bound forms leading to cell transformation (Lin et al. Guanosine Diphosphate cell division cycle 42 Homo sapiens
2 Here, we describe the backbone dynamics of Cdc42Hs(F28L)-GDP using 1H-15N NMR measurements of T1, T1rho, and steady-state NOE at two magnetic field strengths. Guanosine Diphosphate cell division cycle 42 Homo sapiens