Pub. Date : 2004 Aug
PMID : 15286096
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The purpose of this study was to evaluate the effect of itraconazole, a known P-gp inhibitor, on the renal tubular secretion of cimetidine in healthy volunteers who received intravenous cimetidine alone and following 3 days of oral itraconazole (400 mg/day) administration. | Itraconazole | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | The increased systemic exposure of cimetidine during coadministration with itraconazole was likely due to inhibition of P-gp-mediated renal tubular secretion. | Itraconazole | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | Further evaluation of renal P-gp-modulating drugs such as itraconazole that may alter the renal excretion of coadministered drugs is warranted. | Itraconazole | ATP binding cassette subfamily B member 1 | Homo sapiens |