Title : Nitric oxide counteracts angiotensin II induced contraction in efferent arterioles in mice.

Pub. Date : 2004 Aug

PMID : 15283756






2 Functional Relationships(s)
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1 Pre-treatment with N(G)-Nitro-L-arginine-methylester (l-NAME) (10(-4) mol L(-1)) increased the Ang II sensitivity in retrograde (17 +/- 9%) and orthograde perfused Ef (19 +/- 9%). NG-Nitroarginine Methyl Ester angiotensinogen (serpin peptidase inhibitor, clade A, member 8) Mus musculus
2 CONCLUSION: The increased Ang II sensitivity during L-NAME pre-treatment and in eNOS(-/-) mice indicates a strong counteraction of endothelial derived NO on Ang II induced contraction in Ef. NG-Nitroarginine Methyl Ester angiotensinogen (serpin peptidase inhibitor, clade A, member 8) Mus musculus