Title : Antizyme targets cyclin D1 for degradation. A novel mechanism for cell growth repression.

Pub. Date : 2004 Oct 1

PMID : 15277517






3 Functional Relationships(s)
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1 We demonstrate that antizyme is capable of specific, noncovalent association with cyclin D1 and that this interaction accelerates cyclin D1 degradation in vitro in the presence of only antizyme, cyclin D1, purified 26 S proteasomes, and ATP. Adenosine Triphosphate cyclin D1 Homo sapiens
2 We demonstrate that antizyme is capable of specific, noncovalent association with cyclin D1 and that this interaction accelerates cyclin D1 degradation in vitro in the presence of only antizyme, cyclin D1, purified 26 S proteasomes, and ATP. Adenosine Triphosphate cyclin D1 Homo sapiens
3 We demonstrate that antizyme is capable of specific, noncovalent association with cyclin D1 and that this interaction accelerates cyclin D1 degradation in vitro in the presence of only antizyme, cyclin D1, purified 26 S proteasomes, and ATP. Adenosine Triphosphate cyclin D1 Homo sapiens