Title : Inducible nuclear factor-kappaB activation contributes to chemotherapy resistance in gastric cancer.

Pub. Date : 2004 Aug

PMID : 15275881






2 Functional Relationships(s)
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1 Inhibition of NF-kappaB by adenoviral delivery of an IkappaBalpha superrepressor (Ad.IkappaBalpha-SR) should potentiate 5-fluorouracil (5-FU) and irinotecan chemotherapy in gastric cancer cells. Irinotecan nuclear factor kappa B subunit 1 Homo sapiens
2 RESULTS: 5-FU and SN-38 significantly induced NF-kappaB activation as measured by luciferase reporter assay (p < 0.001). Irinotecan nuclear factor kappa B subunit 1 Homo sapiens