Title : Quantum chemical calculations and mutational analysis suggest heat shock protein 90 catalyzes trans-cis isomerization of geldanamycin.

Pub. Date : 2004 Jul

PMID : 15271357






1 Functional Relationships(s)
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1 In support of this model, we show that radicicol binds equally well to both wild-type HSP90 and the Ser113 mutant, whereas the binding of GA to the Ser113 mutant is decreased significantly from its binding to wild-type HSP90. monorden heat shock protein 90 alpha family class A member 1 Homo sapiens