Title : Reduction of vascular noradrenaline sensitivity by AT1 antagonists depends on functional sympathetic innervation.

Pub. Date : 2004 Sep

PMID : 15262904






4 Functional Relationships(s)
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1 Reduction of vascular noradrenaline sensitivity by AT1 antagonists depends on functional sympathetic innervation. Norepinephrine angiotensin II receptor, type 1a Rattus norvegicus
2 Blockade of angiotensin II type-1 (AT1) receptors has been shown to reduce the magnitude of the blood pressure response to noradrenaline in pithed rats via an unidentified mechanism. Norepinephrine angiotensin II receptor, type 1a Rattus norvegicus
3 Our experiments show that the reduction of vascular noradrenaline sensitivity by AT1 blockade is dependent on the intact functioning of both neuronal noradrenaline uptake via norepinephrine transporter and presynaptic alpha2-mediated autoinhibition, exclusively provided by the sympathetic innervation. Norepinephrine angiotensin II receptor, type 1a Rattus norvegicus
4 Our experiments show that the reduction of vascular noradrenaline sensitivity by AT1 blockade is dependent on the intact functioning of both neuronal noradrenaline uptake via norepinephrine transporter and presynaptic alpha2-mediated autoinhibition, exclusively provided by the sympathetic innervation. Norepinephrine angiotensin II receptor, type 1a Rattus norvegicus