Pub. Date : 2004 Oct
PMID : 15258194
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Niacin noncompetitively inhibits DGAT2 but not DGAT1 activity in HepG2 cells. | Niacin | diacylglycerol O-acyltransferase 1 | Homo sapiens |
| 2 | In this report, using HepG2 cells, we have examined the effect of niacin on the mRNA expression and microsomal activity of diacylglycerol acyltransferase 1 and 2 (DGAT1 and DGAT2), the last committed but distinctly different enzymes for triglyceride synthesis. | Niacin | diacylglycerol O-acyltransferase 1 | Homo sapiens |
| 3 | Addition of niacin to the DGAT assay reaction mixture dose-dependently (0-3 mM) inhibited DGAT activity by 35-50%, and the IC(50) was found to be 0.1 mM. | Niacin | diacylglycerol O-acyltransferase 1 | Homo sapiens |
| 4 | Addition of niacin to the DGAT assay reaction mixture dose-dependently (0-3 mM) inhibited DGAT activity by 35-50%, and the IC(50) was found to be 0.1 mM. | Niacin | diacylglycerol O-acyltransferase 1 | Homo sapiens |
| 5 | A Lineweaver-Burk plot of DGAT inhibition by niacin showed a noncompetitive type of inhibition. | Niacin | diacylglycerol O-acyltransferase 1 | Homo sapiens |
| 6 | Niacin selectively inhibited DGAT2 but not DGAT1 activity. | Niacin | diacylglycerol O-acyltransferase 1 | Homo sapiens |
| 7 | Niacin inhibited overt DGAT activity. | Niacin | diacylglycerol O-acyltransferase 1 | Homo sapiens |