Title : Effects of iridoid total glycoside from Cornus officinalis on prevention of glomerular overexpression of transforming growth factor beta 1 and matrixes in an experimental diabetes model.

Pub. Date : 2004 Jul

PMID : 15256732






2 Functional Relationships(s)
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1 The present study was conducted to determine whether iridoid total glycoside from Cornus officinalis was effective in regulating expression of transforming growth factor beta 1 (TGF-beta1) and preventing overdeposition of extracellular matrix (ECM) in a diabetes state. Glycosides transforming growth factor, beta 1 Rattus norvegicus
2 Both iridoid total glycoside and aminoguanidine were effective in decreasing serum protein level and glomerular mRNA expression of TGF-beta1, and in preventing renal overdeposition of fibronectin and laminin. Glycosides transforming growth factor, beta 1 Rattus norvegicus