Title : Role of phospholipase D signaling in ethanol-induced inhibition of carbachol-stimulated DNA synthesis of 1321N1 astrocytoma cells.

Pub. Date : 2004 Aug

PMID : 15255942






2 Functional Relationships(s)
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1 Taken together, these results indicate that PLD activation plays an important role in carbachol-induced astroglial cell proliferation by generating the second messenger PA, which activates PKC zeta. Phosphatidic Acids glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens
2 Moreover, the effect of ethanol on carbachol-induced proliferation appears to be mediated, at least in part, by its ability to interact with PLD leading to a decreased synthesis of PA. Phosphatidic Acids glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens