Title : Transport of SN-38 by the wild type of human ABC transporter ABCG2 and its inhibition by quercetin, a natural flavonoid.

Pub. Date : 2004 Apr

PMID : 15255290






2 Functional Relationships(s)
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Protein Name
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1 In plasma membrane vesicles prepared from the ABCG2 variant cDNA-transfected HEK293 cells, [Arg482]ABCG2 transported SN-38 and its glucuronide conjugate in an ATP-dependent manner; however, only minimal transport activities were observed with the other variants (Gly482 and Thr482). Glucuronides ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens
2 In plasma membrane vesicles prepared from the ABCG2 variant cDNA-transfected HEK293 cells, [Arg482]ABCG2 transported SN-38 and its glucuronide conjugate in an ATP-dependent manner; however, only minimal transport activities were observed with the other variants (Gly482 and Thr482). Glucuronides ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens