Pub. Date : 2004 Jul
PMID : 15252145
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We recently reported that nobiletin (5,6,7,8,3",4"-hexamethoxy flavone) exhibits novel antitumor invasive activities by suppressing the production of pro-matrix metalloproteinases (proMMPs) and augmenting the expression of tissue inhibitor of metalloproteinases-1 (TIMP-1) in vivo and in vitro. | nobiletin | TIMP metallopeptidase inhibitor 1 | Homo sapiens |
| 2 | We recently reported that nobiletin (5,6,7,8,3",4"-hexamethoxy flavone) exhibits novel antitumor invasive activities by suppressing the production of pro-matrix metalloproteinases (proMMPs) and augmenting the expression of tissue inhibitor of metalloproteinases-1 (TIMP-1) in vivo and in vitro. | nobiletin | TIMP metallopeptidase inhibitor 1 | Homo sapiens |
| 3 | We recently reported that nobiletin (5,6,7,8,3",4"-hexamethoxy flavone) exhibits novel antitumor invasive activities by suppressing the production of pro-matrix metalloproteinases (proMMPs) and augmenting the expression of tissue inhibitor of metalloproteinases-1 (TIMP-1) in vivo and in vitro. | nobiletin | TIMP metallopeptidase inhibitor 1 | Homo sapiens |
| 4 | We recently reported that nobiletin (5,6,7,8,3",4"-hexamethoxy flavone) exhibits novel antitumor invasive activities by suppressing the production of pro-matrix metalloproteinases (proMMPs) and augmenting the expression of tissue inhibitor of metalloproteinases-1 (TIMP-1) in vivo and in vitro. | nobiletin | TIMP metallopeptidase inhibitor 1 | Homo sapiens |
| 5 | Therefore, these results introduce novel evidence that the antitumor effects of nobiletin are finely regulated by the following intracellular mechanisms: (1) the inhibition of MEK1/2 activity is involved in the suppression of MMP expression and (2) the activation of the novel PKCbetaII/epsilon-JNK pathway is associated with the augmentation of TIMP-1 expression. | nobiletin | TIMP metallopeptidase inhibitor 1 | Homo sapiens |