Title : Nicotinic and muscarinic acetylcholine receptors are essential for the long-term response of tyrosine hydroxylase gene expression to chronic nicotine treatment in rat adrenal medulla.

Pub. Date : 2004 Jul 26

PMID : 15249143






1 Functional Relationships(s)
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1 Repeated injections of the mAChR agonist bethanechol (5 mg/kg injected twice per day for 7 days) also produced increases in TH mRNA levels; however, TH protein levels and TH activity did not increase in response to bethanechol. Bethanechol tyrosine hydroxylase Rattus norvegicus